©2019 by Tedesco Lab.

Principal Investigator

FRANCESCO SAVERIO TEDESCO MD PhD FHEA MRCPCH

Associate Professor of Stem Cells and Regenerative Medicine &

NIHR Clinical Lecturer in Paediatrics

Department of Cell and Developmental Biology, Division of Biosciences & Dubowitz Neuromuscular Centre, Great Ormond Street Institute of Child Health, University College London, London, UK

Dr. Tedesco is a clinician-scientist with a special interest in muscle regeneration. He graduated in Medicine and Surgery with honours at the University of Rome “La Sapienza” (Italy). He then continued his studies at San Raffaele Scientific Institute (Milan, Italy), where he obtained his PhD in 2010 studying novel gene and cell therapy strategies for muscular dystrophy. Before and during his PhD studies he was a visiting scientist at the Institut Pasteur (Paris, France) and afterwards he coupled post-doctoral research and clinical training between Italy (San Raffaele Hospital, Milan) and UK (UCL and UCL Hospitals). He received several awards and research grants, including an NIHR Academic Clinical Fellowship and then a Clinical Lectureship in Paediatrics, the European Society for Gene and Cell Therapy 2015 Young Investigator Award and, more recently, a European Research Council (ERC) Starting Grant. He is one of the Leads of the recently established London Stem Cell Network.

SHILPITA SARCAR PhD

Visiting post-doctoral fellow

Shilpita completed her PhD in Medical Sciences from the Free University of Brussels and is now a post doc in the Tedesco lab. Prior to her PhD, she worked at StemPeutics Research pvt ltd in Bangalore. Her work involves developing novel gene and cell based therapeutic approaches for the treatment of different forms of muscular dystrophies; this also includes generation of complex artificial 3D muscles for the purpose of disease modeling and drug screening. Currently, she is also looking at ways to improve maturation in the complex artificial 3D muscles.

GIULIA FERRARI MD

Post-doctoral fellow

Giulia graduated in Medicine and Surgery with honours in 2014 at the University of Bologna (Italy). During and after medical school, she has been a visiting student in the laboratories of Dr Nicola Valeri and Dr Chiara Braconi at the Beatson Institute (Glasgow) and Institute Cancer Research (London). She completed her MDUK-funded PhD in Stem Cells and Regenerative Medicine in the Tedesco lab. Specifically, she is combining Human Artificial Chromosomes, induced pluripotent stem cells (iPSCs) and cell fate modulators to develop an enhanced gene and cell therapy approach to treat muscular dystrophies.

ALEXANDER HENDERSON

PhD Student

Alex did his BSc at Royal Holloway University of London working on satellite cell activation. He then undertook an MRes in Gene and Cell Therapy at UCL, working on muscle tissue engineering and vascular cell differentiation using human iPS, cells under the supervision of Dr Tedesco. Alex is currently a PhD student of the BBSRC iCASE programme, working on genomic stability in bioprocessing at GSK and UCL.

LUCA PINTON

PhD Student

Luca graduated in Pharmacy at the University of Ferrara (Italy) with honours in 2015 after undertaking an internship at Karolinska Institute (Sweden) in Fuxe lab looking at receptor-receptor interactions in several models of rat brain. He is a PhD candidate within the BBSRC London Interdisciplinary Doctoral (LIDo) programme jointly supervised by Dr Francesco Saverio Tedesco and Prof Peter Zammit (KCL). He is currently looking at skeletal muscle and peripheral nerve laminopathies using patient-specific iPSC-derived disease models utilising both 2D and 3D organoids platforms with the ultimate goal of screening new candidate drugs and testing novel gene therapies. He is also a Coordinator of the London Stem Cell Network as well as Business Development Director at Innovation Forum.

MOUSTAFA KHEDR

PhD Student

Moustafa graduated from UCL with an MRes degree in Stem Cells and Developmental Biology, during which, he worked at Prof. Paolo De Coppi’s lab at the Great Ormond street Institute of Child Health on developing an ExtraCellular Matrix Derived Hydrogel derived from porcine intestines as a support for 3D organoid cultures. Prior to this, he was a research and teaching assistant at the American University in Cairo where he also obtained his BSc-Hons in Molecular and Cell Biology. He is currently working on modelling Duchenne muscular dystrophy using iPSC-derived 3D organoids with an MDUK-funded PhD studentship (second supervisor: Prof. Francesco Muntoni). Outside the lab, Moustafa is the Vice President of Apollo London Society and a Vice President at Innovation Forum.

  

DANIEL MOORE

MRes Student

Daniel graduated In Biochemistry from University College Cork (Ireland) with a year spent at the University of California, Santa Barbara (USA). During his undergraduate studies, he undertook projects to create a low-cost biosensor system to detect antibiotics in milk products and to create a series of reporter plasmids to measure IL-8 expression. He is currently undertaking an MRes Biosciences - Stem Cell and Developmental Biology, supervised by Dr. Francesco Saverio Tedesco. Using patient-derived iPSC lines, he is examining skeletal muscle laminopathies and methods to model the disease in the laboratory.

MENGMENG ZHU

MRes Student

Mengmeng graduated in biotechnology at the Jiangxi Agricultural University (China) and University of Newcastle (Australia).  During her BSc, she undertook a project to identify candidate proteins associated with bull fertility which may be used for diagnostic purposes and selective breeding programs. She is an MRes Biosciences student under the supervision of Dr. Francesco Saverio Tedesco. Currently, she is working with Moustafa on the dystrophin-tracking 3D muscle disease modeling platform.

SUNGWOO CHOI

MSci Student

SungWoo is an undergraduate student enrolled in an integrated masters program, MSci Cell Biology at University College London.  He is currently looking at muscle stem cell migration in muscle cell therapy.

OUR TEAM

PREVIOUS MEMBERS

POST DOCTORAL FELLOWS & PHD STUDENTS

SARA BENEDETTI

Sara was a post-doctoral fellow in the Tedesco Lab working on multiple muscle gene and cell therapy projects. Afterwards she joined the UCL Great Ormond Street Institute of Child Health as Lecturer in Gene Therapy.

MATTIA F. M. GERLI

Mattia was a PhD student in the Tedesco Lab working on hiPSC-derived myogenesis and cell fate modulation. Soon afterwards he joined the Ott Lab at Harvard University as post-doctoral fellow.

HIDETOSHI HOSHIYA

Hidetoshi was a post-doctoral fellow in the Tedesco Lab working on human artificial chromosome engineering. He then joined the Cell and Gene Therapy Catapult as Transactions Manager for Asia.

SARA MARTINA MAFFIOLETTI

Sara was a PhD student in the Tedesco Lab working on hiPSC-derived myogenesis and muscle tissue engineering. She then joined the Ditadi Group at the San Raffaele Institute of Milan as an EMBO post-doctoral fellow.

LOUISE ANNE MOYLE

Louise was a post-doctoral fellow in the Tedesco Lab working on muscle stem cell fate modulation. She then moved to the Gilbert Lab at the University of Toronto as a post-doctoral fellow.

HEATHER STEELE-STALLARD

Heather was a BBSRC LIDo PhD student in the Tedesco Lab working on muscle disease modelling using hiPSCs. She then joined the University of Oxford for a post-grad medical degree (BM BCh).

STELLA-ORJONA TASO

Stella was a lab manager in the Tedesco Lab. After which she joined 

ELISABETTA DE MARCO

Elisabetta is an ERASMUS MSc. student MSc. in Pharmaceutical Biotechnology at University of Padua (Italy) who completed her project in the Tedesco Lab. She is currently finishing her studies and looking for PhD opportunities.

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RESEARCH ASSISTANTS, MASTERS STUDENTS & VISITING MEMBERS

Coming soon